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Translational Informatics, Biostatistics and Epidemiology Lab

What do we do?

The Translational Informatics, Biostatistics and Epidemiology laboratory (TIBE Labs) led by Dr. Arthur Owora applies novel biostatistical and machine learning methodologies to different (structured and unstructured) and multiple data sources (active and passive) to generate analytics and insights regarding disease etiology, risk, and prognosis. Through collaboration with clinicians, the TIBE laboratory aims to translate such insights to inform effective clinical decision-making at point-of-care including more proactive and personalized care, for improved patient-centered outcomes in real-world healthcare settings.

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Research Funding

Developing a Childhood Asthma Risk Passive Digital Marker

K01HL163462 | Owora (PI) | 12/01/2022-11/30/2026​

 

To develop and determine the usability, acceptability, feasibility, and preliminary efficacy of a childhood asthma Passive Digital Marker (PDM) for early disease detection. Here, a PDM refers to a ML algorithm that can be used to retrieve and synthesize pre-existing ‘Passively’ collected mother/child dyad prognostic data (i.e., medical history) at ages 0-3 years in ‘Digital’ EHR to provide an objective and quantifiable ‘Marker’ of a child’s asthma risk and phenotype at ages 6-10 years.
 

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Recent Publications

(* student mentees/advisees)

Owora AH, Houghton RF, Ferrand JL, Parker E, Anderson P, Coyle K, Guinosso S, Walsh-Buhi ER. Promoting Healthy Adolescent Romantic Relationships: Results of a Multisite, Two-group Parallel Randomized Clinical Trial. J Adolesc Health. 2024 Jul;75(1):162-172. doi: 10.1016/j.jadohealth.2024.02.025. Epub 2024 May 10. PubMed PMID: 38727657.

Aguree S, Owora A, Hawkins M, Gletsu-Miller N. Obesity modifies the association between diabetes and iron biomarkers and red cell indices in reproductive-aged women in the United States. J Investig Med. 2024 Jun;72(5):425-437. doi: 10.1177/10815589241240059. Epub 2024 May 14. PubMed PMID: 38445643.

Jacobs W, Qin W, Riley TN, Parker ES, Owora AH, Leventhal A. Race/ethnic differences in the association of anxiety, depression, and discrimination with subsequent nicotine and cannabis use among young adults: A prospective longitudinal study. Addict Behav. 2024 Jun;153:107979. doi: 10.1016/j.addbeh.2024.107979. Epub 2024 Feb 3. PubMed PMID: 38394958; PubMed Central PMCID: PMC11152197.

Rogerson C, Owora A, Tu W, Mendonca E. The influence of social and environmental determinants of health on hospitalizations for pediatric asthma. J Asthma. 2024 May;61(5):453-462. doi: 10.1080/02770903.2023.2288323. Epub 2023 Dec 1. PubMed PMID: 38010826.

Gupta P, Doherty L, Temprosa M, Pop-Busui R, Gadde KM, Singh P, Owora AH, Wessells H, Sarma AV. Prevalence and predictors of female sexual dysfunction among sexually active women in the diabetes prevention program outcomes study. Neurourol Urodyn. 2024 Apr;43(4):977-990. doi: 10.1002/nau.25436. Epub 2024 Mar 19. PubMed PMID: 38501372.

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